I am using this approach for dynamic loading:
http://cknotes.com/dynamically-loading-net-assembly-32-bit-or-64-bit/
It failed on the line var assembly = Assembly.LoadFrom(path);
with FileLoadException : Could not load file or assembly "file:///C:UsersabcDocumentsVisual Studio 2010ProjectsproblembinDebugChilkatDotNet4-32.dll" or one of its dependencies. Operation is not supported. (Exception from HRESULT: 0x80131515)